Dette kan måles i hvile eller underneath bevegelser, person kan snakke om smerte i øyeblikket eller gjennom en periode, og spesifisere om man snakker om gjennomsnitt for perioden eller minste eller verste smerte.1897: Den tyske kjemikeren Felix Hoffmann i firmaet Bayer fremstiller det smertestillende legemiddelet acetylsalisylsyre. Utgangsstoffet
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